Absence of clinical disease and contact transmission of HPAI H5NX clade 2.3.4.4 from North America in experimentally infected pigs

ConclusionsH5NX clade 2.3.4.4 strains can replicate in the lower respiratory tract of swine upon high titer inoculation, though appear to be incapable of replication in swine nasal epithelium in vivo or ex vivo in trachea explants in culture. Infected pigs did not produce high levels of serum antibodies following infection. Collectively, our data show HPAI H5NX clade 2.3.4.4 viruses to be poorly adapted for replication and transmission in swine.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Firv.12463

Source: Influenza and Other Respiratory Viruses - September 2, 2017 Category: Virology Authors: Bryan S. Kaplan, Mia K. Torchetti, Kelly M. Lager, Richard J. Webby, Amy L. Vincent Tags: ORIGINAL ARTICLE Source Type: research