Application of Adverse Outcome Pathways to U.S. EPA ’s Endocrine Disruptor Screening Program

Conclusions:
A variety of biological systems affect apical end points used in regulatory risk assessments, and without mechanistic data, an endocrine mode of action cannot be determined. Because the EDSP was designed to consider mode of action, toxicity pathway and AOP concepts are a natural fit. Pathway frameworks have diverse applications to endocrine screening and testing. An estrogen pathway example is presented, and similar approaches are being used to evaluate alternative methods and develop predictive models for androgen and thyroid pathways. https://doi.org/10.1289/EHP1304

Received: 31 October 2016
Revised: 13 June 2017
Accepted: 22 June 2017
Published: 01 September 2017
Address correspondence to P. Browne, Environment Health and Safety Division, Environment Directorate, Organisation for Economic Co-operation and Development, 2, rue André Pascal, 75775 Paris Cedex 16, France. Telephone: [phone]. Email: [e-mail]
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - September 1, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research