Hearts lacking plasma membrane KATP channels display changes in basal aerobic metabolic substrate preference and AMPK activity

In this study, we show that genetic ablation of plasma membrane ATP-sensitive K+ channels results in pronounced changes in cardiac metabolic substrate preference and AMP-activated protein kinase activity. These results suggest that ATP-sensitive K+ channels may play a novel role in regulating metabolism in addition to their well-documented effects on ionic homeostasis during periods of stress.

Source: AJP: Heart and Circulatory Physiology - September 1, 2017 Category: Cardiology Authors: Youssef, N., Campbell, S., Barr, A., Gandhi, M., Hunter, B., Dolinsky, V., Dyck, J. R. B., Clanachan, A. S., Light, P. E. Tags: RESEARCH ARTICLE Source Type: research