Reconsider logP!

In our view, it is essential to start a general balanced but unprejudiced discussion on power and limitations of methods and predictive models in radiopharmacy. We fully agree, that lipophilicity has a significant impact on the pharmacokinetic properties of radiopharmaceuticals, and we literally stated in our manuscript: “In drug development, especially for central applications, the lipophilicity is a pivotal and early indicator of the potential in vivo pharmacokinetic and dynamic behaviour. Lipophilicity measurements, as it is widely known, provide information about unspecific binding, metabolic stability, plasma protein binding, the distribution and excretion of drugs.” [1] However, we do not want to rely on a single and simplified physicochemical value to predict complex biochemical processes in vivo.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research