High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spontaneous glutamate inputs

This study suggests that NTS-CA neurons are glucosensing through a presynaptic mechanism that is dependent on vagal glutamate release, 5-HT3R activity, and glucokinase.

Source: AJP: Regulatory, Integrative and Comparative Physiology - September 1, 2017 Category: Physiology Authors: Roberts, B. L., Zhu, M., Zhao, H., Dillon, C., Appleyard, S. M. Tags: Research Article Source Type: research