Therapeutic targeting of the angiopoietin – TIE pathway

Nature Reviews Drug Discovery 16, 635 (2017). doi:10.1038/nrd.2016.278 Authors: Pipsa Saharinen, Lauri Eklund & Kari Alitalo The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological applications. The aim is to complement current vascular endothelial growth
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research