Therapeutic targeting of the angiopoietin – TIE pathway
Nature Reviews Drug Discovery 16, 635 (2017).
doi:10.1038/nrd.2016.278
Authors: Pipsa Saharinen, Lauri Eklund & Kari Alitalo
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological applications. The aim is to complement current vascular endothelial growth
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Pipsa Saharinen Lauri Eklund Kari Alitalo Tags: Review Source Type: research