Cancer: Inhibiting ROCK in neuroblastoma

Nature Reviews Drug Discovery 16, 602 (2017). doi:10.1038/nrd.2017.160 Author: Crunkhorn Sarah Neuroblastoma is a childhood tumour originating from the neural crest, for which treatment options are limited. Dyberg et al. report a high frequency of mutations in genes associated with RHO–RAC signalling in human neuroblastoma samples. Increased expression of the downstream RHO-activating kinase ROCK2 was
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research