Anticancer agents: Fighting resistance

Nature Reviews Drug Discovery 16, 602 (2017). doi:10.1038/nrd.2017.157 Author: Crunkhorn Sarah RAF–MEK–ERK pathway inhibitors are used to treat cancers exhibiting BRAFV600E mutations, but drug resistance commonly develops. Here, analysis of patient-derived xenograft (PDX) of BRAFV600E-mutant cancers and single-cell DNA sequencing showed that following drug treatment, parallel evolutionary tracts enable the selection and
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research