Differentially Methylated Circulating DNA: a Novel Biomarker to Monitor Beta Cell Death

Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarkers, such as C-peptide and islet autoimmune antibodies are limited to reflect beta cell death and to identify high risk patients in the clinical practice. Recently, a novel biomarker, differentially methylated circulating DNA, has become a research hotspot.

Source: Journal of Diabetes and Its Complications - August 30, 2017 Category: Endocrinology Authors: Yingfeng Liu, Qiyuan Tan, Fang Liu Tags: Review article Source Type: research