Tools for exploring mouse models of human disease

Publication date: Available online 30 August 2017 Source:Drug Discovery Today: Disease Models Author(s): Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research