Loopholes in the DNA contract kill neurons
Nature Neuroscience 20, 1192 (2017).
doi:10.1038/nn.4626
Authors: Karl Herrup, Kai-Hei Tse & Hei-Man Chow
Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.
Source: Nature Neuroscience - Category: Neuroscience Authors: Karl Herrup Kai-Hei Tse Hei-Man Chow Tags: News and Views Source Type: research
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