Cross-sectional and longitudinal small animal PET shows pre and post-synaptic striatal dopaminergic deficits in an animal model of HIV

In vivo imaging biomarkers of various HIV neuropathologies, including dopaminergic dysfunction, are still lacking. Towards developing dopaminergic biomarkers of brain involvement in HIV, we assessed the pre and postsynaptic components of the dopaminergic system in the HIV-1 transgenic rat (Tg), a well-characterized model of treated HIV+ patients, using small-animal PET imaging.

Source: Nuclear Medicine and Biology - August 29, 2017 Category: Nuclear Medicine Authors: Sanhita Sinharay, Dianne Lee, Swati Shah, Siva Muthusamy, Georgios Z. Papadakis, Xiang Zhang, Dragan Maric, William C. Reid, Dima A. Hammoud Source Type: research