Genome ‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type
Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC‐SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC‐SABP, we have performed a replication study using independent RDC‐SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p‐value <10−5 for RDC‐SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta‐analysis (combined RDC‐SABP, n = 423, controls, n = 9,494), we observed genome‐wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p‐value, 4.37 × 10−8). This locus did not reach genome‐wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - Category: Genetics & Stem Cells Authors: Elaine K. Green, Arianna Di Florio, Liz Forty, Katherine Gordon ‐Smith, Detelina Grozeva, Christine Fraser, Alexander L. Richards, Jennifer L. Moran, Shaun Purcell, Pamela Sklar, George Kirov, Michael J. Owen, Michael C. O'Donovan, Nick Craddock, Lisa J Tags: RESEARCH ARTICLE Source Type: research