Dual function of Lactobacillus kefiri DH5 in preventing high ‐fat‐diet‐induced obesity: direct reduction of cholesterol and upregulation of PPAR‐α in adipose tissue

ConclusionL. kefiri DH5 exerts anti‐obesity effects by direct reduction of cholesterol in the lumen and upregulation of PPAR‐α gene in adipose tissues. The proposed dual mechanism underlying the anti‐obesity and anti‐non‐alcoholic fatty liver disease (NAFLD) effects of L. kefiri DH5 in high‐fat diet (HFD)‐fed mice was explored. A large proportion of the orally administered L. kefiri DH5 remains active and viable in the gastrointestinal tract and exerts potent anti‐obesity effects in HFD‐fed mice via a dual mechanism: (i) direct reduction of excessive cholesterol in the lumen to decrease overall fat influx, and (ii) upregulation of genes encoding PPAR‐α, CPT1, and FABP4 in adipose tissue to increase fatty acid oxidation.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: Research Article Source Type: research