Estradiol promotes epithelial ‐to‐mesenchymal transition in human benign prostatic epithelial cells

ConclusionsEstrogenic effect mediated by ERα can promote EMT. E2 is also an inductive factor of cell phenotypic switching. Cell type modulation is associated with E2‐induced EMT in benign prostatic epithelial cells. Taken together the results support a contribution of estrogens to the pathogenesis of BPH in elderly men.

Source: The Prostate - August 29, 2017 Category: Urology & Nephrology Authors: Xiaoyu Shi, Yanfei Peng, Xiaoling Du, Haitao Liu, Helmut Klocker, Qimei Lin, Jiandang Shi, Ju Zhang Tags: ORIGINAL ARTICLE Source Type: research