Biology and clinical relevance of noncoding sno/scaRNAs
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Thuy Cao, Sheeja Rajasingh, Saheli Samanta, Buddhadeb Dawn, Douglas C. Bittel, Johnson Rajasingh Source Type: research
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