Let it snow: Emerging roles for snoRNAs in cardiovascular disease

Despite prevention and current therapies, cardiovascular disease and its attendant complications remains the number one cause of morbidity and mortality in Western societies. While current therapeutics target protein-coding genes representing 2% of the genome, accumulating studies reveal that a large portion of the non-coding genome is actively transcribed and ~50% of these transcripts are small RNAs and long non-coding RNAs [1,2]. Emerging studies have begun to unravel specific species of non-coding RNAs as critical mediators of pathological signaling pathways and cellular responses important for a range of cardiovascular disease states [3,4].
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research