Prevention of 5-fluorouracil –induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: The multiparametric approach is not convincing
Life-threatening toxicities induced by widely-prescribed fluoropyrimidines remain a critical issue. Despite the accumulation for decades of evidence showing that dihydropyrimidine dehydrogenase (DPD) deficiency is a leading cause of 5-fluorouracil (5FU)-related toxicities [1 –3], there is still no consensus on the best strategy for identifying patients at risk. Upfront DPD screening has been recommended by the Clinical Pharmacogenetics Implementation Consortium [4], as well as by several national societies of biologists such as the Royal Dutch Pharmacists Association, the Italian Society of Pharmacology, and the French Groupe de Pharmacologie Clinique Oncologique (GPCO)-Unicancer group [5].
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Marie-Christine Etienne-Grimaldi, Chantal Barin Le Guellec, Jean-Christophe Boyer, Etienne Chatelut, Alexandre Evrard, Marie-Anne Loriot, Angelo Paci, Bernard Royer, Fabienne Thomas, Joseph Ciccolini Tags: Letter to the Editor Source Type: research
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