Targeting androgen-independent pathways: new chances for patients with prostate cancer?

Prostate cancer (PC) accounts for 1 in 5 new diagnoses of cancer in the United States of America and, despite the recent improvements, this neoplasm still causes more than 26,000 deaths per year (Siegel et al., 2016). The prostate gland is constituted both of basal and luminal epithelium arranged in a fibro-muscular stromal network (Packer and Maitland, 2016). Based on the observation that human PC are mostly luminal-like adenocarcinomas, the luminal origin of PC is supported by several studies (Wang et al., 2009; Wang et al., 2014).

Source: Critical Reviews in Oncology Hematology - August 28, 2017 Category: Cancer & Oncology Authors: C. Cattrini, E. Zanardi, G. Vallome, A. Cavo, L. Cerbone, A. Di Meglio, C. Fabbroni, M.M. Latocca, F. Rizzo, C. Messina, A. Rubagotti, P. Barboro, F. Boccardo Source Type: research