Delivery of Therapeutic Proteins Using Electrospun Fibers —Recent Developments and Current Challenges

Proteins play a vital role within the human body by regulating various functions and even serving as structural constituent of many body parts. In this context, protein‐based therapeutics have attracted a lot of attention in the last few decades as potential treatment of different diseases. Due to the steadily increasing interest in protein‐based therapeutics, different dosage forms were investigated for delivering such complex macromolecules to the human body. Here, electrospun fibers hold a great potential for embedding proteins without structural damage and for controlled release of the protein for therapeutic applications. This review provides a comprehensive overview of the current state of protein‐based carrier systems using electrospun fibers, with special emphasis on discussing their potential and key challenges in developing such therapeutic strategies, along with a prospective view of anticipated future directions. Electrospun fibers hold great potential for embedding proteins for controlled release of the protein for therapeutic applications. This review provides a comprehensive overview of the current state of protein‐based carrier systems using electrospun fibers with special emphasis on their potential and the key challenges in developing such therapeutic strategies.
Source: Archiv der Pharmazie - Category: Drugs & Pharmacology Authors: Tags: Minireview Source Type: research