Association of Functional SNP -1562C > T in MMP9 Promoter with Proliferative Diabetic Retinopathy in north Indian type 2 Diabetes Mellitus patients

Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP -1562 C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population.
Source: Journal of Diabetes and Its Complications - Category: Endocrinology Authors: Source Type: research