Comparison between [18F]fluorination and [18F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [18F]MNI-659

2-(2-(3-(4-(2-[18F]Fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ([18F]MNI-659, [18F]1) is a useful PET radiotracer for imaging phosphodiesterase 10A (PDE10A) in human brain. [18F]1 has been previously prepared by direct [18F]fluorination of a tosylate precursor 2 with [18F]F-. The aim of this study was to determine the conditions for the [18F]fluorination reaction to obtain [18F]1 of high quality and with sufficient radioactivity for clinical use in our institute.

Source: Nuclear Medicine and Biology - August 25, 2017 Category: Nuclear Medicine Authors: Wakana Mori, Makoto Takei, Kenji Furutsuka, Masayuki Fujinaga, Katsushi Kumata, Masatoshi Muto, Takayuki Ohkubo, Hiroki Hashimoto, Gilles Tamagnan, Makoto Higuchi, Kazunori Kawamura, Ming-Rong Zhang Source Type: research