Connexin ‐43 and aquaporin‐4 are markers of ageing‐related tau astrogliopathy (ARTAG)‐related astroglial response

DiscussionOur study reveals distinctive astroglial responses in each of the locations associated with ARTAG. Our observations support the concept that factors related to brain‐fluid interfaces and water‐ion imbalances most likely play a role in the generation of ARTAG. As Cx43 is crucial for maintaining neuronal homeostasis, the ARTAG‐dependent increase of Cx43 density of IR suggests that the development of ARTAG in the GM most likely indicates an early response to the degeneration of neurons.

Source: Neuropathology and Applied Neurobiology - August 25, 2017 Category: Neurology Authors: G. G. Kovacs, A. Yousef, S. Kaindl, V. M. Lee, J. Q. Trojanowski Tags: Original Article Source Type: research