Development of Protein –Protein Interaction Inhibitors for the Treatment of Infectious Diseases

Publication date: Available online 24 August 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Andrew F. Voter, James L. Keck Protein–protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible for making PPI inhibitors realistic targets for therapeutic intervention and brief outlook of the field.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research