Multivalent methionine ‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR

ConclusionsThe synthesized polymer vector can deliver siRNA molecules into tumor cells and then reverse drug resistance by down regulation of P‐glycoprotein mRNA expression.

Source: The Journal of Gene Medicine - August 25, 2017 Category: Genetics & Stem Cells Authors: Yang Wu, Wei Zhang, Tinghan Li, Rong Ma, Dan Chen, Junying Zhang, Jianzhong Wu, Jinhai Tang Tags: RESEARCH ARTICLE Source Type: research