Blood antimicrobial activity varies against different Mycobacterium spp.
In vitro analysis of mycobacterial pathogenicity or host susceptibility has traditionally relied on the infection of macrophages, the target cell of mycobacteria, despite difficulties reproducing their antimycobacterial activity. We have employed alternative models, namely whole blood and leukocytes in plasma, from QuantiFERON negative individuals, and performed infections with the pathogenic M. tuberculosis, the less pathogenic M. avium, M. kansasii and M. chelonae and the occasionally pathogenic M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Octavio Miguel Rivero-Lezcano, Sara Blanco-Conde, Ramiro L ópez-Medrano, Eduardo López-Fidalgo, Manuela Caño-Herrero, Teresa Nebreda-Mayoral Tags: Immunological Aspects Source Type: research