The expressions and roles of different forms of IL-22 in Mycobacterium tuberculosis infection

Despite evidence suggesting an anti-Mycobacterium tuberculosis effector function of CD4+ T cells that produce and retain IL-22 in macaques, the general role of IL-22 in tuberculosis infection is still poorly characterized. To explore the immune mechanism in the pathogenesis of tuberculosis in humans, here we evaluated different forms of IL-22 in populations with different tuberculosis infection statuses. We enrolled 156 subjects including 49 patients with pulmonary tuberculosis, 27 patients with tuberculous pleurisy (TPE), 38 individuals with latent tuberculous infection (LTBI) and 42 healthy controls (HC).

Source: Tuberculosis - August 24, 2017 Category: Respiratory Medicine Authors: Yuanyuan Liu, Qinfang Ou, Qianqian Liu, Yan Gao, Jing Wu, Bingyan Zhang, Xinhua Weng, Lingyun Shao, Wenhong Zhang Tags: Immunological Aspects Source Type: research