Pharmacological Evaluation of Novel Isonicotinic Carboxamide Derivatives as Potential Anti ‐Hyperlipidemic and Antioxidant Agents

This study revealed the antihyperlipidemic activities of some of the newly synthesized, novel carboxamide derivatives, mainly C4 and C12 (p < 0.05). The majority of the compounds displayed a relatively low or no DPPH radical scavenging effect, with C20 possessing the best radical scavenging effect (22%) among all. This research opens the door for new potential antihyperlipidemic compounds derived from isonicotinic acid. N‐(3‐Benzoylphenyl)pyridine‐4‐carboxamide (C4) was found to have promising lipid‐lowering and antioxidant effects, which may create a protective effect against CVDs, by reducing the LDL‐C levels and diminishing the generation of reactive oxygen species. Novel N‐(benzoylphenyl)pyridine‐4‐carboxamide and N‐(9,10‐dioxo‐9,10‐dihydroanthracenyl)pyridine‐4‐carboxamide derivatives were studied for their activities in controlling hyperlipidemia and oxidative stress. N‐(3‐Benzoylphenyl)pyridine‐4‐carboxamide showed promising lipid‐lowering and antioxidant effects, which may provide protection against cardiovascular diseases.
Source: Archiv der Pharmazie - Category: Drugs & Pharmacology Authors: Tags: Full Paper Source Type: research