Increase of n ‐NOS and i‐NOS in Rat Colon After Sacral Neuromodulation

ConclusionOur study showed that in colon, SNM is able to influence NO synthesis, activating n‐NOS expression in muscle cells and i‐NOS expression in glandular epithelium and nervous cells. Our study showed a complex colonic response to SNM. This experimental model could be applied to better understand the mechanism of action of SNM in bowel dysfunction.

Source: Neuromodulation - August 1, 2017 Category: Neurology Authors: Roberto Ghiselli, Guendalina Lucarini, Fiorenza Orlando, Monica Ortenzi, Luca Cardinali, Mauro Provinciali, Roberto Di Primio, Mario Guerrieri Tags: Basic Research Source Type: research