Reptin regulates insulin ‐stimulated Akt phosphorylation in hepatocellular carcinoma via the regulation of SHP‐1/PTPN6

In conclusion, we have uncovered a new function for Reptin in regulating insulin signalling in HCC cells via the regulation of SHP‐1 expression. We suggest that the regulation of insulin sensitivity by Reptin contributes to its oncogenic action in the liver.

Source: Cell Biochemistry and Function - August 22, 2017 Category: Biochemistry Authors: Anne ‐Aurélie Raymond, Joaquim Javary, Osman Breig, Véronique Neaud, Jean Rosenbaum Tags: RESEARCH ARTICLE Source Type: research