Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

Publication date: Available online 15 August 2017 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Sireesha Malladi, R. Venkata Nadh, K. Suresh Babu, P. Suri Babu 2,4 disubstitiuted furan derivatives (8A–8M) were prepared from furan-4-carboxylic acid ethyl ester (1). Antibacterial activity of new 2,4 di substituted furan derivatives was studied against Gram (+) and Gram (−) bacteria. 8F, 8E, 8D and 8J were found to be effective against Gram (−) bacteria whereas, 8A and 8L were effective against Gram (+) bacteria. Least MIC value was found as 100µg/ml against Escherichia coli (for 8D and 8F), and Proteus vulgaris (for 8E and 8F). Antibacterial activity is correlated with different substituents. Products exhibited better antibacterial activities especially towards Streptococcus pyogenes, Proteus vulgaris, and Escherichia coli. Graphical abstract
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research