Network analyses identify liver-specific targets for treating liver diseases

In conclusion, we identified liver-specific genes linked to NAFLD pathogenesis, such as pyruvate kinase liver and red blood cell (PKLR), or to HCC pathogenesis, such as PKLR, patatin-like phospholipase domain containing 3 (PNPLA3), and proprotein convertase subtilisin/kexin type 9 (PCSK9), all of which are potential targets for drug development.

Source: Molecular Systems Biology - August 21, 2017 Category: Molecular Biology Authors: Lee, S., Zhang, C., Liu, Z., Klevstig, M., Mukhopadhyay, B., Bergentall, M., Cinar, R., Stahlman, M., Sikanic, N., Park, J. K., Deshmukh, S., Harzandi, A. M., Kuijpers, T., Grotli, M., Elsässer, S. J., Piening, B. D., Snyder, M., Smith, U., Nielse Tags: Genome-Scale & Integrative Biology, Molecular Biology of Disease, Network Biology Articles Source Type: research