Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification using an independent prospective breast cancer cohort and external patient populations

Conclusions: Both prospective internal cohorts and the independent external cohorts reproduced the triad classification of CMTC and its prognostic significance. CMTC is an independent prognostic predictor, and it outperformed 12 other known prognostic gene signatures, molecular subtype classifications, and all other standard prognostic clinicopathological factors. Our results support further development of CMTC portfolio into a guide for personalized breast cancer treatments.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research