COMT val158met polymorphism links to altered fear conditioning and extinction are modulated by PTSD and childhood trauma

ConclusionsThese findings support the hypothesis that G × E interactions underlie associations of COMT val158met with fear inhibition deficits. These studies confirm that Met/Met carriers with PTSD have poor fear inhibition, and support further research in understanding how this polymorphism might impact response to extinction‐based therapies.

Source: Depression and Anxiety - August 1, 2017 Category: Psychiatry Authors: Jessica Deslauriers, Dean T. Acheson, Adam X. Maihofer, Caroline M. Nievergelt, Dewleen G. Baker, Mark A. Geyer, Victoria B. Risbrough, Tags: RESEARCH ARTICLE Source Type: research