Putative binding sites for mir ‐125 family miRNAs in the mouse Lfng 3′UTR affect transcript expression in the segmentation clock, but mir‐125a‐5p is dispensable for normal somitogenesis

Conclusions: These results suggest that mir‐125a sites in the Lfng 3′ untranslated region influence transcript turnover in both mouse and chicken embryos, and support the existence of position‐dependent regulatory mechanisms in the PSM. They further suggest the existence of compensatory mechanisms that can rescue the loss of mir‐125a‐5p in mice. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc.

Source: Developmental Dynamics - August 18, 2017 Category: Molecular Biology Authors: Kanu Wahi, Sophia Friesen, Vincenzo Coppola, Susan E. Cole Tags: Research Article Source Type: research