In vitro Antimicrobial and in vivo Lead Acetate Poison Abatement Study of Garcinia kola Heckel

Publication date: Available online 28 June 2017 Source:Journal of Taibah University for Science Author(s): Omorefosa Osarenkhoe Osemwegie, Charles Obiora Nwonuma, Abimbola Peter Oluyori, Praise Ocheanya Abraham, Abraham Abayomi Akanbi, Deborah Oluyemisi Opaleke, Omokolade Oluwaseyi Alejolowo The in vitro antimicrobial and in vivo heavy metal abatement properties of aqueous extracts of Garcinia kola Heckel (bitter cola) were investigated using opportunistic pathogens and Wistar rats as experimental models. A marked inhibitory activity against Aspergillus niger, Aspergillus flavus and Candida albicans was recorded at 100mg/ml of the crude relative to ketoconozole and fluconazole drugs. Similarly, different concentrations (25mg/ml, 50mg/ml and 100mg/ml) of the crude extracts of bitter cola inhibited species of Escherichia coli and Pseudomonas aeruginosa almost as effectively as the control drug of streptomycine used. Chronic lead acetate poisoned wistar rats in groups B, C, D, E exposed to G. kola supplemented feed and water ad libitum showed variable decrease in the serum alkaline phosphatase level while aspartate and alanine aminotransferases level reduces in C and D groups compared to the negative control group. The kidney biomarkers; serum creatinine and urea concentrations were not significantly different at P ≤0.05 for rat groups C, D, E when compared with the positive and negative control groups respectively. Mild infiltration and cell distortion were observed ...
Source: Journal of Taibah University for Science - Category: Science Source Type: research