Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer

The α4β2* nicotinic acetylcholine receptor (nAChR) system is implicated in many neuropsychiatric pathologies. [18F]Nifene is a positron emission tomography (PET) ligand that has shown promise for in vivo imaging of the α4β2* nAChR system in preclinical models and humans. This work establishes the ra diation burden associated with [18F]nifene PET scans in humans.

Source: Nuclear Medicine and Biology - August 17, 2017 Category: Nuclear Medicine Authors: Tobey J. Betthauser, Ansel T. Hillmer, Patrick J. Lao, Emily Ehlerding, Jogeshwar Mukherjee, Charles K. Stone, Bradley T. Christian Source Type: research