Extraneural relapse of medulloblastoma mimicking acute leukemia: A diagnostic challenge in adult patient

We present a case of young adult with relapsed medulloblastoma with extraneural metastases in the bone marrow and expression of terminal deoxynucleotidyl transferase (TdT) on the malignant cells mimicking acute leukemia. To the best of our knowledge, this is the first report of medulloblastoma exhibiting expression of the TdT in adult. We would like to emphasize that in cases like this, differential diagnosis of anemia and thrombocytopenia in adults should include a consideration of the primary or secondary bone marrow involvement by the medulloblastoma or the other rare malignancy.
Source: Acta Haematologica Polonica - Category: Hematology Source Type: research