‐318C/T polymorphism of the CTLA‐4 gene is an independent risk factor for RBC alloimmunization among sickle cell disease patients

In conclusion, the polymorphism ‐318C/T of CTLA‐4 gene is associated with RBC alloimmunization among SCD patients. This highlights the role played by CTLA‐4 on post‐transfusion alloantibody development.

Source: International Journal of Immunogenetics - August 1, 2017 Category: Genetics & Stem Cells Authors: V. B. Oliveira, M. R. Dezan, F. C. A. Gomes, S. F. Menosi Gualandro, J. E. Krieger, A. C. Pereira, J. D. Marsiglia, J. E. Levi, V. Rocha, A. Mendrone ‐Junior, E. C. Sabino, C. L. Dinardo Tags: ORIGINAL ARTICLE Source Type: research