Placenta growth factor mediated gene regulation in sickle cell disease

Sickle cell anemia (SCA) is an autosomal recessive disorder caused by mutation in the β-globin gene. Pulmonary hypertension (PH), a complication of SCA, results in severe morbidity and mortality. PH is a multifactorial disease: systemic vasculopathy, pulmonary vasoconstriction, and endothelial dysfunction and remodeling. Placenta growth factor (PlGF), an angiogenic growth factor, el aborated from erythroid cells, has been shown to contribute to inflammation, pulmonary vasoconstriction and airway hyper-responsiveness (AH) in mouse models of sickle cell disease.

Source: Blood Reviews - August 16, 2017 Category: Hematology Authors: Vijay K. Kalra, Shuxiao Zhang, Punam Malik, Stanley M. Tahara Tags: Review Source Type: research