Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-Ib{Delta}C-X Mice [Original Articles]

Conclusions— The most prominent alterations of the gene program linked to CREM-induced atrial remodeling were identified in the expression of genes related to structure, metabolism, contractility, and electric activity regulation, suggesting that CREM transgenic mice are a valuable experimental model for human AF pathophysiology.

http://circep.ahajournals.org/cgi/content/short/10/8/e005075?rss=1

Source: Circulation: Arrhythmia and Electrophysiology - August 7, 2017 Category: Cardiology Authors: Seidl, M. D., Stein, J., Hamer, S., Pluteanu, F., Scholz, B., Wardelmann, E., Huge, A., Witten, A., Stoll, M., Hammer, E., Volker, U., Muller, F. U. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation, Animal Models of Human Disease, Gene Expression & Regulation Original Articles Source Type: research