Impact of Timing on the Functional Recovery Achieved With Platelet Supplementation After Treatment With Ticagrelor [Coronary Artery Disease]

Conclusions—
Platelet reactivity of ticagrelor-treated patients can be restored using concentrated platelets after a loading dose/maintenance therapy in a time-dependent manner under in vitro testing. Although statistically significant improvements are evident 6 hours after (last) dosing, ≤24 hours maybe needed for clinically meaningful restoration in platelet function.

Clinical Trial Registration—
URL: https://clinicaltrials.gov. Unique identifier: NCT02201394.

Source: Circulation: Cardiovascular Interventions - August 2, 2017 Category: Cardiology Authors: Zafar, M. U., Smith, D. A., Baber, U., Sartori, S., Chen, K., Lam, D. W., Linares-Koloffon, C. A., Rey-Mendoza, J., Jimenez Britez, G., Escolar, G., Fuster, V., Badimon, J. J. Tags: Clinical Studies, Translational Studies, Cardiovascular Surgery Coronary Artery Disease Source Type: research