HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Conclusions: Taken together, our results demonstrate upregulation of HDAC1 and 2 in CHF. In addition, HDAC inhibition reverses interstitial fibrosis in CHF. Possible anti-fibrotic actions of HDAC inhibition include reversal of myofibroblast activation and induction of cell cycle arrest / apoptosis.

http://www.fibrogenesis.com/content/7/1/10

Source: Fibrogenesis and Tissue Repair - July 2, 2014 Category: Biomedical Science Authors: Hikmet Nural-GuvenerLuidmila ZakharovaJames NimlosSnjezana PopovicDiego MastroeniMohamed Gaballa Source Type: research