Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis [Original Articles]

Conclusions— We have identified variants that may assist in the diagnosis of at least 6.3% of autopsy-negative child SUD cases and reduce risk of future SUD in surviving relatives. We recommend a cautious approach to variant interpretation. We also suggest inclusion of cardiomyopathy genes as well as other candidate SUD genes in molecular autopsy analyses.

http://circgenetics.ahajournals.org/cgi/content/short/10/4/e001738?rss=1

Source: Circulation: Cardiovascular Genetics - August 14, 2017 Category: Cardiology Authors: Dewar, L. J., Alcaide, M., Fornika, D., DAmato, L., Shafaatalab, S., Stevens, C. M., Balachandra, T., Phillips, S. M., Sanatani, S., Morin, R. D., Tibbits, G. F. Tags: Arrhythmias, Sudden Cardiac Death, Ion Channels/Membrane Transport, Genetics, Cardiomyopathy Original Articles Source Type: research