A positron emission tomography study of the serotonergic system in relation to anxiety in depression

Symptoms of anxiety are highly comorbid with major depressive disorder (MDD) and are known to alter the course of the disease. To help elucidate the biological underpinnings of these prevalent disorders, we previously examined the relationship between components of anxiety (somatic, psychic and motoric) and serotonin 1A receptor (5-HT1A) binding in MDD and found that higher psychic and lower somatic anxiety was associated with greater 5-HT1A binding. In this work, we sought to examine the correlation between these anxiety symptom dimensions and 5-HTT binding.

Source: European Neuropsychopharmacology - August 12, 2017 Category: Psychiatry & Psychology Authors: Zafer Iscan, Gopalkumar Rakesh, Samantha Rossano, Jie Yang, Mengru Zhang, Jeffrey Miller, Gregory M. Sullivan, Priya Sharma, Matthew McClure, Maria A. Oquendo, J. John Mann, Ramin V. Parsey, Christine DeLorenzo Source Type: research