Host blood RNA signatures predict the outcome of tuberculosis treatment

Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of whole blood from a well-characterized TB treatment cohort was performed. Application of a validated transcriptional correlate of risk for TB revealed symmetry in host gene expression during progression from latent TB infection to active TB disease and resolution of disease during treatment, including return to control levels after drug therapy.

Source: Tuberculosis - August 11, 2017 Category: Respiratory Medicine Authors: Ethan G. Thompson, Ying Du, Stephanus T. Malherbe, Smitha Shankar, Jackie Braun, Joe Valvo, Katharina Ronacher, Gerard Tromp, David L. Tabb, David Alland, Shubhada Shenai, Laura E. Via, James Warwick, Alan Aderem, Thomas J. Scriba, Jill Winter, Gerhard Wa Source Type: research