GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice

In conclusion, increased Hb O2 affinity enhanced physiological tolerance to hypoxia, as evidenced by improved hemodynamics and tissue oxygenation. Therefore, pharmacologically induced increases in Hb O2 affinity become a potential therapeutic approach to improve tissue oxygenation in pulmonary diseases characterized by severe hypoxemia.
NEW & NOTEWORTHY This study establishes that pharmacological modification of hemoglobin O2 affinity can be a promising and novel therapeutic strategy for the treatment of hypoxic hypoxia and paves the way for the clinical development of molecules that prevent hypoxemia.

Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Dufu, K., Yalcin, O., Ao-ieong, E. S. Y., Hutchaleelala, A., Xu, Q., Li, Z., Vlahakis, N., Oksenberg, D., Lehrer-Graiwer, J., Cabrales, P. Tags: RESEARCH ARTICLE Source Type: research