Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a TH1 response

In this study, we have investigated the role of this cell wall associated protein in activation of macrophages by toll like receptor (TLRs) enga gement and subsequent signaling. Our results showed that MymA stimulation of THP1 cells and human monocyte derived macrophages (MDM) lead to upregulation of TLR2 and co-stimulatory molecules CD40, CD80, CD86 and HLA-DR.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Source Type: research