mRNA mediates passive vaccination against infectious agents, toxins, and tumors

In conclusion, the present study demonstrates the utility of formulated mRNA as a potent novel technology for passive immunization.

As a transient carrier of information, exogenous mRNA is considered a possibly powerful tool to instruct a body to produce its own therapeutics. Antibody‐encoding, sequence‐optimized but otherwise unmodified mRNA in LNPs empowered mice to successfully fight various biological threats.

Source: EMBO Molecular Medicine - August 1, 2017 Category: Molecular Biology Authors: Moritz Thran, Jean Mukherjee, Marion P önisch, Katja Fiedler, Andreas Thess, Barbara L Mui, Michael J Hope, Ying K Tam, Nigel Horscroft, Regina Heidenreich, Mariola Fotin‐Mleczek, Charles B Shoemaker, Thomas Schlake Tags: Research Article Source Type: research