Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p

This article describes structural and biochemical characterization of the interactions between the Xpo1p nuclear export complex and the FG repeats of Nup42p, a nucleoporin localized at the cytoplasmic face of nuclear pore complexes in yeast. The results of this study extend our understanding of the role of Nup42p in the terminal stage of nuclear export. The structure presented here also provides insights into evolutionary conservation of the FG repeat binding sites on CRM1 (Xpo1p) across species.

Source: Genes to Cells - August 1, 2017 Category: Genetics & Stem Cells Authors: Masako Koyama, Hidemi Hirano, Natsuki Shirai, Yoshiyuki Matsuura Tags: Original Article Source Type: research